Hannah Cockroft won gold in the T33/34 100m ahead of England team-mates Kare Adenegan and Fabienne Andre.
Cockroft, who has seven Paralympic titles to her name, was competing at the Commonwealth Games for the first time and made no mistake as she set a new Games record time of 16.84.
The 30-year-old was followed home by Adenegan in a season's-best time, with bronze going to Andre.
"That crowd just wants you to go out there. When you hear that noise. It took me back 10 years," Cockroft said.
"It took me back to the Paralympics and I revelled in it."
It was the first day of competition at the Alexander Stadium with six medals handed out.
Pole vault gold went to Australia's Nina Kennedy, with England's Molly Caudery delighting the home crowd with silver after team-mate Holly Bradshaw was forced to withdraw.
Bradshaw, who won Olympic bronze last year, failed to recover from the hamstring injury she suffered in a freak accident at the World Championships.
Her pole broke during her final practice jump – seeing her land awkwardly and hurt her hamstring – and she had to pull out in Eugene. At the Alexander Stadium, after testing the injury prior to the competition, she was unable to compete.
She said: “I had a scan after my incident in the worlds and I had a partial tear of my hamstring and tendon. I vaulted on Saturday very tentatively and I thought I would be OK but in my warm up I felt something pop.
“This was going to be my last Commonwealth Games and a chance of a medal but it wasn’t meant to be. I’m glad I gave it a go and wasn’t sat at home.”
Pole vault bronze was won by New Zealand's Imogen Ayris.
Uganda's Jacob Kiplimo set a new Games record en route to gold in the men's 10,000m, leading home Kenya's Daniel Simiu Ebenyo and Kibiwott Kandie.
The 21-year-old Kiplimo, who won bronze at both the 2020 Tokyo Olympics and world championships last month, posted a time of 27.09.19.
The women's T37/38 100m was won by a beaming Olivia Breen.
The 26-year-old from Wales beat English favourite Sophie Hahn, with New Zealand's Rhiannon Clarke taking bronze.
Breen said: "It's taken nine years and I've waited for this day. I feel absolutely on top of the world. This is the best day of my life."
Gold in the men's T45/47 went to England's Emmanuel Temitayo Oyinbo-Coker, heading Australia's Jaydon Page and England's Ola Abidogun.
This is the best day of my life
In the other medal event of the night, Nigeria won gold in the women's discus as Chioma Onyekwere saw off the challenge of England's Jade Lally.
Onyekwere threw a season's best 61.70 to land gold, with team-mate Obiageri Amaechi taking bronze.
Defending champion Katarina Johnson-Thompson is eyeing a return to the top as she bids for a first heptathlon title in three years.
The 29-year-old is the overnight leader after a solid first day.
Johnson-Thompson sits on 3765 points, 109 ahead of Northern Ireland’s Kate O’Connor.
The pandemic and two serious Achilles and calf injuries have stopped Johnson-Thompson winning a title since the World Championships in 2019 but she is closing in on a defence in Birmingham.
She said: “It’s really nice, in 2018 this competition was the platform for me to win global medals so hopefully this will be it again and my transition back.
“It’s hard to be confident when my results have happened over the last year but I’m confident in myself, I’m enjoying it, I’m happy, it’s all I can do.
“I got two season’s best and two weeks post jetlag, travel and heptathlon (from the World Championships) I wasn’t really expecting them. I’m really happy, feeling good and feel like I recovered well.
“It’s been tough but I’ve been pushing so much this season I was happy to have a week off, it was nice being at home, not training and letting my body recover.
“It’s my last competition of the year so hopefully it will be a nice way to finish off the season.”