It is the final day of competition in the swimming, while the headline act of the Athletics takes place at Alexander Stadium.
Here, we pick out five things to keep an eye out for on day six of Birmingham 2022.
Blue riband Athletics event
The must-see moments of any Athletics meet happen on Wednesday with the final of the men's and women's 100m at the Alexander Stadium.
Kenya's Ferdinand Omanyala, who has the third fastest time in the world this season, put in an ominous display with the second fastest time of the men's heats - behind Sri Lanka's Yupun Abeykoon.
Defending champion Akani Simbine, of South Africa, qualified impressively in winning his heat with the fourth fastest overall time.
Jamaica's Elaine Thompson-Herah, favourite for the women's title, laid down a marker with the joint-fastest heat time of 10.99.
Mountain Bike gold battle
England's Evie Richards goes for gold in the women's Cross-Country Mountain Bike event, bidding to better the silver she won four years ago.
Richards, who finished seventh in the Olympics last year, would love to put a year of injury and illness behind her but said she must be realistic after months of back problems and a recent bout of Covid – potentially opening the door for Scotland’s Isla Short.
New Zealand’s defending champion Sam Gaze is favourite in the men’s race.
Final day in the pool
The curtain comes down on the Swimming action in Birmingham with a raft of medals up for grabs on the final evening.
Defending Commonwealth and Olympic champion Ariarne Titmus, of Australia, goes in the women's 400m freestyle.
Australia will be out for more gold as Mitchell Larkin defends his 200m individual medley crown, while the green and gold will be favourites in the men's and women's individual medley 4x100 relay.
India-Barbados Cricket showdown
Australia are safely through in Group A ahead of their clash with Pakistan, but the battle to join them will be tense when India face Barbados at 6pm.
India were narrowly beaten by favourites Australia before thrashing rivals Pakistan, while Barbados were soundly beaten by the world champions after opening with victory over Pakistan.
First Squash gold
Wales' Joel Makin takes on New Zealand's Paul Coll in the men's final, with Makin having stunned defending champion James Willstrop in the semi-finals.
Canada's Hollie Naughton beat defending champion Joelle King to reach the women's final where she faces England's Georgina Kennedy.